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Stem Cells & Healing?

Anyway it may take more than 24 hrs x 365 days x 100 years to win or loose. I can do that but I don't have more time to waste in repetions, TTTT & yes or no, because neither you nor me are GOD--A&F. So try to make better use of time.

To the topic;-

I am trying to understand relation between iron homeostsis & stem cells activities. This also combine issues related to my both recent topics. Pls contribute if you can otherwise learn or ignore. Good bye homeopathy & TTTT from this point.
 
Kumar said:
Anyway it may take more than 24 hrs x 365 days x 100 years to win or loose. I can do that but I don't have more time to waste in repetions, TTTT & yes or no, because neither you nor me are GOD--A&F. So try to make better use of time.
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If you would like to avoid repetition, I would suggest not creating identical threads 3 years apart. Also, understanding the information you receive would help. And accepting that "A&F" is a childish fantasy.

Kumar said:
To the topic;-

I am trying to understand relation between iron homeostsis & stem cells activities. This also combine issues related to my both recent topics. Pls contribute if you can otherwise learn or ignore. Good bye homeopathy & TTTT from this point.
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Ok, what role do you think iron homeostasis plays in stem cell activities, and what role do you think stem cells play in healing?
 
Kumar said:
Whatever you feel/find is your property & choice.

Better, henceforth use "experimental medicine" instead of "real medicine"
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There's no point, Kumar, because nothing is ever A&F. We go by our best experimental and objective data. So far, all experimental and objective data which is reliable points to homeopathy being useless. Yes, we could be wrong. But to show us that we're wrong, you have to provide evidence!
 
Kumar said:
Same you are trying. How can you say for A & F that homeopathic remedies are just water and sugar? uptill you are A & F?
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Jesus...

NOTHING WILL EVER BE A&F!!!

Got it? We go by the current experimental data. If, later, homeopathy is proven to be true, we will accept that too. But to do so, you have to actually provide some evidence!

Arg!
 
Kumar said:
Anyway it may take more than 24 hrs x 365 days x 100 years to win or loose. I can do that but I don't have more time to waste in repetions, TTTT & yes or no, because neither you nor me are GOD--A&F. So try to make better use of time.
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Nothing will EVER be A&F, Kumar. That only exists in Mathematics. That is why, when we say "proven", we do not mean "A&F" but "to the best of our knowledge, based on the scientific evidence", because that is the best we can ever hope for. Given that, homeopathy has been proven to be wrong, because science shows us it doesn't work, and no evidence for its efficacy has been presented.

To the topic;-

I am trying to understand relation between iron homeostsis & stem cells activities. This also combine issues related to my both recent topics. Pls contribute if you can otherwise learn or ignore. Good bye homeopathy & TTTT from this point.
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Ok. How do you think these things work?
 
Kumar said:
Because you use "real medicine" word. Till these are A & F with out adversities probably these neither justify real nor medicine but otherwise can.
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No, they can justify it if clinically relevant results can be demonstrated in properly conducted trials. That's how we tell the difference between medicine and sCAM.
 
Giggywig said:
If you would like to avoid repetition, I would suggest not creating identical threads 3 years apart. Also, understanding the information you receive would help. And accepting that "A&F" is a childish fantasy.
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Ok as you want.


Ok, what role do you think iron homeostasis plays in stem cell activities, and what role do you think stem cells play in healing?
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I just think, they can also behave in the manner other live cells can behave because they are also live cells.

We should differenciate between embroynic & adult stem cells. Former are involved in development & stem cells therapies and later in cleaning, repairing & remodeling injured site as indicted here;

Adult stem cells are undifferentiated cells, found throughout the body after embryonic development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. Also known as somatic stem cells (from Greek Σωματικóς, meaning of the body), they can be found in juvenile as well as adult animals and humans.

Scientific interest in adult stem cells has centered on their ability to divide or self-renew indefinitely, and generate all the cell types of the organ from which they originate, potentially regenerating the entire organ from a few cells.
http://en.wikipedia.org/wiki/Adult_stem_cell
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Although role of blood cells--WBCs, RBCs & platelets which also come from Hematopoietic stem cells and involved immune response & O2 homeostatis, I used word cleaning the site free from infectious & non infectious odds.
 
Kumar said:
I just think, they can also behave in the manner other live cells can behave because they are also live cells.
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I'm not sure what this was supposed to answer. Also, define "the manner of other live cells" because your typical complex organism has a lot of specialized cells that do very specialized things.

Kumar said:
We should differenciate between embroynic & adult stem cells.
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I'm quite sure the people in the relevant fields do.
Kumar said:
Former are involved in development & stem cells therapies and later in cleaning, repairing & remodeling injured site as indicted here;
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You'd have to specify what you mean by "cleaning, repairing & remodeling injured site."

Kumar said:
Although role of blood cells--WBCs, RBCs & platelets which also come from Hematopoietic stem cells and involved immune response & O2 homeostatis, I used word cleaning the site free from infectious & non infectious odds.
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You lost your sense making abilities there. Please rephrase.
 
Giggywig said:
I'm not sure what this was supposed to answer. Also, define "the manner of other live cells" because your typical complex organism has a lot of specialized cells that do very specialized things.
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It is there in OP of my other topic on Iron. Yes.


I'm quite sure the people in the relevant fields do.
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Yes but It appear that they have not made it a part of defence mechanism to heal.

You'd have to specify what you mean by "cleaning, repairing & remodeling injured site."


You lost your sense making abilities there. Please rephrase.
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I think you have not read quote I provided.

"Adult stem cells are undifferentiated cells, found throughout the body after embryonic development, that multiply by cell division to replenish dying cells and regenerate damaged tissues."

However role of Hematopoietic stem cells and thereafter of blood cells is not directly indicated which can just be clealing the injured site from infectious & non infectious odds unabling final healing/remodeling.
 
Kumar said:
You are using "real" word which should be A & F, but probably it may just justify "experimental" instead.
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No, wrong.

We know what is real by experiment.

I mean real. Real medicine, as opposed the evil and ridiculous fraud that is homeopathy.

Is it demonstrable effect against illness and injury or demonstrable cure against illness and injury?
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Effect.

Beta blockers don't cure heart damage. They do significantly reduce mortality. That's real medicine.

Because HBP is a life long disorder, I may want to see life long DBPC studies.
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Why? You don't give a damn about blinding, placebos, randomisation, experimental control, plausibility, mechanism, or even common sense when it comes to your pet quackery. You don't even understand them.

People at mass are convinced with you about earth shape but nt yet with homeopathy.
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As I said, idiots.
 
Whatever you feel/find/ about homeopathy is need to be right here. So avoid wasting further time and contribute more to topic subject.

Whether stem cells are dependant on iron?
 
Kumar said:
Whatever you feel/find/ about homeopathy is need to be right here.
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Homeopathy doesn't work. That's established scientific fact, Kumar.

So avoid wasting further time and contribute more to topic subject.
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We are not wasting time. You may be, if you continue to ignore the opportunities for learning that are available to you.

Whether stem cells are dependant on iron?
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Sorry, you don't understand the question.
 
PixyMisa said:
Homeopathy doesn't work. That's established scientific fact, Kumar.


We are not wasting time. You may be, if you continue to ignore the opportunities for learning that are available to you.


Sorry, you don't understand the question.
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Try to concentrate more on visible harming/fatal substances than on non harming substances, if you want to really contribute to humanity. Such substances should be existing at mass--eg. alcohol, tobbacco, pollutions creating tools, global warming tools, unhygenic foods, crowding, unnecessary & avoidable use of healing agents having side/adverse effects, harming cloths & houses etc.
 
To the topic again:-

Did you know that physiological normoxia generally falls in the 2-9% O2 (14.4-64.8 mm Hg) range for most adult cells in vivo? 3 remarkable exceptions are thymus, kidney medulla and most importantly bone marrow which can exist at 1% O2 (7.2 mm Hg). On the other hand, stem and progenitor cells are frequent residents of hypoxic niches and low O2 regulates their differentiation.
http://pimm.wordpress.com/2008/04/02/oxygen-control-of-stem-cell-niches-and-cell-fates/

Molecular oxygen is absolutely essential for cellular respiration and higher organisms have developed sophisticated physiological responses that allow adaptation to a low oxygen environment (hypoxia). Recent studies indicate that embryonic stem and progenitor cells reside in hypoxic 'niches' and low oxygen regulates their differentiation. The molecular mechanisms underling the regulation of stem cells during hypoxia is in part mediated by the activation of hypoxia-inducible factors (HIFs). The goal of the symposia is to (1) the importance of hypoxia in stem cell maintenance and embryonic development, (2) the cellular and molecular mechanisms that underlie physiological responses to hypoxia and (3) role of stem cells as therapy for hypoxia related diseases.

http://www.the-aps.org/meetings/eb09/abs/hypoxia-chandel.htm

Many other articles on PubMed also indicate similar understanding.
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Above quotes suggest stem cells relation to Oxygen level(indirectly to iron homeostsis). As such, we can try evaluation O2/iron instabilties with stem cell activities(dormacy, compromising, activation, growth, differenciation, inactivation, weakening, death of stem cell's activities). Probably modren lifestyle, unhygiene, crowding & environmental insults and other practices should be effecting our stm cell mechanism for normal healing.
 
Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells


Abstract
Background
The balance between self-renewal and differentiation of stem cells is expected to be tightly controlled in order to maintain tissue homeostasis throughout life, also in the face of environmental hazards. Theory, predicting that homeostasis is maintained by a negative feedback on stem cell proliferation, implies a Quorum Sensing mechanism in higher vertebrates.

Conclusions
This study suggests that stem cell immortalization may be triggered by reduced intercellular communication, rather than exclusively result from somatic evolution, and implies that stem cell proliferation can be attenuated by signal manipulation, or enhanced by cytotoxics targeted to differentiated cells. In vivo verification and identification of the Quorum Sensing mediating molecules will pave the way to a higher level control of stem cell proliferation in cancer and in tissue engineering.
http://www.biology-direct.com/content/5/1/20
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This is also good & recent article on topic.
 
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