Questions about Diabetes?

Let me try here:-

How gastric acid, hemoglobin level, iron level or oxygen level in blood can effect the glucose metabolism/BG levels?
 
RECIPE TIME!!!

All in, please! I'd like one on really good clam chowder.
 
Badly Shaved Monkey said:
[HandInAir]Ooh...Ooh...I know..I know...
[/GivesUpAndLetsSomeoneElseAnswer]
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For the millionth time, a combination of wishful thinking and coincidental recovery.

Rolfe.
 
Are these the replies of my question?

Carbohydrate metabolism is much more efficient than fat metabolism assuming adequate oxygen is available (ie aerobic metabolism). But once VO2max has been reached, and anaerobic metabolism takes over, the efficiency of carbohydrate metabolism drops off dramatically. Carbohydrate will produce 19 times as many units of ATP per gram when metabolized in the presence of adequate cell oxygen supplies (aerobic) as opposed to its metabolism in an oxygen deficient (anaerobic) environment.http://www.cptips.com/bscphys.htm
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Is it right that when insulin is in excess in blood (natural, induced or injected), it will convert excess/some glucose into fats OR if it can't put glucose into cells due to IR, it will convert excess/some glucose into fats? How then diabetic patient will be effected---by toxic effects of excess glucose OR of excess fats/lipids OR of hyperinsulinemia? Someone told that excess sugar(may be excess fats) can cause macrovascular complications AND hyperinsulinemia microvascular.
 
Kumar said:
Someone told that ....
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Lots of people in this forum have told you things, Kumar. Why do you ignore them, and refuse to listen to them, but then keep coming back here wittering about what other people have told you?

Rolfe.
 
Kumar,

In excess, glucose is a toxic substance in the body and this is why both type 1 and type 2 diabetics suffer the complications of this. Complications of diabetes are retinopathy, neuropathy and nephropathy. Diabetics can go blind due to this, can loose feeling in their extremeties and can go into renal failure. They can suffer from Peripheral Arterial Disease and Peripheral Vascular Disease.

Insulin is the key if you like that enables the cells of the body to utilise the glucose. If the body is unable to utilise glucose as a source of energy, then it has to use some source, so it will utilise fats instead.

This is why when diabetics are first diagnosed, they can eat lots of food and always seem to be eating, but still losing weight. This is because the body cannot utilise the glucose to use as energy, so has to use fats instead. Once diagnosed and with insulin replacement, the body is then able to utilise the glucose again, so things should stabilise. However, diabetics do then need to eat sensibly and exercise so as to avoid gaining excess weight. They also need to monitor thieir blood glucose levels and keep them within normal range. The more blood glucose is kept within normal ranges, the less likely complications are at a later date.

These complications are the ones mentioned earlier.
 
Rolfe said:
Lots of people in this forum have told you things, Kumar. Why do you ignore them, and refuse to listen to them, but then keep coming back here wittering about what other people have told you?

Rolfe.
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But macrovacular & microvascular differance was not indicated. It was indicated at scicardiology.google group--I think I mentioned link previously. It is very important consideration for excess medicated insulin which can be more dangerous--if this aspect is right.

Sarah,

Sorry, these are regular informations but I asked bit differantly. Diabetics can be also 'weight stay constant & gain weight' esp. in insulin resistance. Whether excess insulin convert excess sugar to fats or not is to be checked?
http://www.annecollins.com/weight_health/diabetes-weight-gain.htm
 
Hey guys, I got an idea. Let's leave Sarah (sorry, Naturalhealth, as he will know her) to handle Kumar.

Rolfe.
 
Good idea, Rolfe.
















Hey! Nothing else has happened for some time. Have they cancelled each other out, perhaps?
 
Diabetes oral medicines(most) & insulin are sulphur based. Can these cause adverse allergic reactions (as sulpha durgs can do) lactic acidosis or acidosis conditions. Can these behave differantly in sulpha senstive persons or in persons who tends to get lactic acid excesses by taking metformin?
 
Kumar said:
Diabetes oral medicines(most) & insulin are sulphur based. Can these cause adverse allergic reactions (as sulpha durgs can do) lactic acidosis or acidosis conditions. Can these behave differantly in sulpha senstive persons or in persons who tends to get lactic acid excesses by taking metformin?
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First, define "sulphur based"
 
re sulfa sensitivity, good question .....but the answer is no. Meformin was discussed previously as was lactic acidosis. I am happy to say that I personally know of no sulfa sensitive diabetic on sulfonyl oral anti diabetic agent who has ever developed an allergic reaction (adverse IgE mediated reaction) to their anti diabetes drug as they would to a sulfa based antimicrobial. The reason has been studied and is given below:

A number of non-antimicrobial drugs such as thiazides, furosemide, some oral anti-diabetes drugs, and celecoxib (Celebrex) contain a sulfonyl component similar to that found in sulfonamide anti-microbial agents. Therefore the use of such agents has been considered contra-indicated in individuals with documented allergy to sulfa antimicrobials. But is there convincing evidence to support this impression?

Almost all of the evidence to support this contention has come from anecdotal case reports, persisting to the present (1,2). However, in a careful review of all the evidence in this area (3), Shapiro and Shear of the Sunnybrook and Women's Health Sciences Centre in Toronto, Canada came to a different conclusion. They pointed out that, in addition to containing the sulfonyl component common to the other agents mentioned, sulfa antimicrobials contain an aromatic amine group at the N4 position, and a substituted ring at the N1 position. Neither feature is present in the non-antimicrobial agents containing the sulfonyl component. The aromatic amine group at the N4 position alone is thought to be critical for the development of the sulfa hypersensitivity reaction and severe skin reactions such as toxic epidermal necrolysis. The substituted ring at the N1 position appears to be critical as the target for IgE-mediated adverse responses to sulfa anti-microbials.

There is no convincing epidemiologic evidence that there is an increased frequency of reactions to the non-antimicrobial agents containing the sulfonyl moiety in those allergic to sulfa anti-microbial agents. The listed contraindications appear to be based on theoretical concepts which do not appear to be valid.

References
1. Mayo Clin Proc. 1997;72(10):930-1.
2. Cutis. 2003 ;71:235-8
3. Drug Saf 2001;24:239-47

http://www.aaaai.org/aadmc/quiz/2003/0703answer.html
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Completely and utterly anecdotal, but my sister-in-law is allergic to sulfa drugs, but took insulin just fine.
 
materia3 said:
re sulfa sensitivity, good question .....but the answer is no. Meformin was discussed previously as was lactic acidosis. I am happy to say that I personally know of no sulfa sensitive diabetic on sulfonyl oral anti diabetic agent who has ever developed an allergic reaction (adverse IgE mediated reaction) to their anti diabetes drug as they would to a sulfa based antimicrobial. The reason has been studied and is given below:
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How metformin or previously DBI develop lactic acidosis? Furthur can these durgs & insulin be related to DKA?

Many factors may contribute to the accumulation of lactic acid that causes lactic acidosis. Congestive heart failure or a temporary but severe fall in blood pressure during a heart attack can lead to a buildup of lactic acid. Metformin should be stopped when one of these conditions is discovered. It should not be used in someone with heart failure or liver disease.

Lactic acid levels increase when strenuous exercise or other conditions (such as heart failure, a severe infection, or shock) reduce the flow of blood and delivery of oxygen throughout the body. Lactic acid levels can also increase when the liver is severely damaged or diseased, because the liver normally breaks down lactic acid.

Do not take GLUCOPHAGE or GLUCOPHAGE XR if you:

have kidney problems
have liver problems
have heart failure that is treated with medicines, such as Lanoxin® (digoxin) or Lasix® (furosemide)
drink a lot of alcohol. This means you binge drink for short periods or drink all the time
are seriously dehydrated (have lost a lot of water from your body)
are going to have an x-ray procedure with injection of dyes (contrast agents)
are going to have surgery
develop a serious condition, such as heart attack, severe infection, or a stroke
are 80 years or older and you have NOT had your kidney function tested
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Can diabetic medicines & insulin cause any of reason of accumulation LA as described above---Low BP/O2 defficiency, infection, liver damage etc. or people who habitually drink less water ?

LDH is most often measured to evaluate the presence of tissue damage. The enzyme LDH is in many body tissues, especially the heart, liver, kidney, skeletal muscle, brain, blood cells, and lungs.

LDH catalyzes the interconversion of pyruvate and lactate. Exercising muscles convert (and red blood cells metabolize) glucose to lactate. Lactate is released into the blood and is eventually taken up by the liver. The liver converts lactate back to glucose and releases glucose into the blood. This glucose is then taken up by resting muscles, red blood cells, and other tissues.
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Can we link progressive damages of above mentioned tissue due to progressive/occasional accumulation of lactate?
 
Lisa Simpson said:
Completely and utterly anecdotal, but my sister-in-law is allergic to sulfa drugs, but took insulin just fine.
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There are two questions. One, whether diabetic durgs & insulin are sulfa allergic? Two, Whether these can cause lactic or other types of acidosis in some patients, if yes, then whether these are not suitable to these type of persons? The awnser to first seems to be no, let us discuss 2nd.
 
Kumar said:
"S" is there in its chemical formula.:)
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Well, find me any biological material that does not. But. in any case, having a sulphur atom in it does not make it "sulphur based"


What's the point you want to make about sulphur?
 
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