Pre-Fertilization Mutations?

[BillHoyt]

Mr.Hans, BH,

I think we are now able to conclude the discussions. It made me more satisfied the root cause of outbreak of modern diabetes is not genetic/hereditary & we can atleast do something for our children. Thanks.

Can you tell me how modern lifestyle changes can cause genetically predisposed people to get diabetes?

Kumar,

We addressed this previously.

Few animals in captivity or by changing their environment do not reproduce or die early, is it by psyclogical or technical reasons?

Where do you get this from?

 

[Kumar]

BH,

"Deoxyribonucleic Acid (DNA): The substance of heredity; a large molecule that carries the genetic information necessary for all cellular functions, including the building of proteins. DNA is composed of the sugar deoxyribose, phosphate, and the bases adenine, thymine, guanine, and cytosine."

Since DNA is a substance for hedidity, sugar deoxyribose, phosphate are part of it. What is the role of sugar deoxyribose, phosphate in heredity?

 

[BillHoyt]

BH,

"Deoxyribonucleic Acid (DNA): The substance of heredity; a large molecule that carries the genetic information necessary for all cellular functions, including the building of proteins. DNA is composed of the sugar deoxyribose, phosphate, and the bases adenine, thymine, guanine, and cytosine."

Since DNA is a substance for hedidity, sugar deoxyribose, phosphate are part of it. What is the role of sugar deoxyribose, phosphate in heredity?

There are no separate roles for the component parts of the molecule.

 

[MRC_Hans]

Kumar, think about water; what are the individual roles of hydrogen and oxygen in water? None. Only bound in the right combination do they become water.

Hans

 

[Kumar]

Mr.Hans,BH,

But is it not so that mutations are only defined in terms of change in adenine, thymine, guanine, and cytosine not in sugar deoxyribose, phosphate. Are these can be somewhat changed on any mutation/damage?

 

[Zep]

Nearly kitty time, folks?

 

[BillHoyt]

Mr.Hans,BH,

But is it not so that mutations are only defined in terms of change in adenine, thymine, guanine, and cytosine not in sugar deoxyribose, phosphate. Are these can be somewhat changed on any mutation/damage?

It is so, Kumar. I'm losing interest and will begin charging you for tutoring.

 

[Kumar]

It is so, Kumar. I'm losing interest and will begin charging you for tutoring.

Don't be tired in jungle search. I already read This.

"A nucleotide is a molecule containing three parts: a simple sugar called deoxyribose, a phosphate, and a special molecule called a nitrogen base. A DNA nucleotide can contain any one of four different nitrogen bases. These are adenine, thymine, guanine and cytosine. Nucleotides join together when the phosphate portion on one bonds with the sugar portion on another".

But I just checked any possibility. Phosphate (along with Sulphur) is very important for my understanding.

 

[Kumar]

What is fundamentally wrong with our modern lifestyle ?

"The last thirty years the amounts of fat in our diets have dropped markedly. However, the populations gets more and more obese. Diabetes II is turning epidemic. More people die early of cancers, strokes, heart-attacks and more modern diseases.

All these diseases didn't exist in the paleolithic age. The few tribes on this planet that still eat like we used to do more than 10.000 years ago, are very healthy. Obese eskimo's don't exist, cancer and diabetes also is non-existant among eskimo's in their natural habitat.Vilhalmur Stefansson, a physician and antropologist already learned this in his many years that he lived among the eskimo's. He hasn't found a single case of cancer in all these years !"

Does it hold some sense?

 

[BillHoyt]

Don't be tired in jungle search. I already read This.

"A nucleotide is a molecule containing three parts: a simple sugar called deoxyribose, a phosphate, and a special molecule called a nitrogen base. A DNA nucleotide can contain any one of four different nitrogen bases. These are adenine, thymine, guanine and cytosine. Nucleotides join together when the phosphate portion on one bonds with the sugar portion on another".

But I just checked any possibility. Phosphate (along with Sulphur) is very important for my understanding.

Kumar,

You either did not go onto page two from your link or didn't understand it. Of course you focus on phosphates and sulphur; they're part of this "cell salts" pseudomedical nonsense you've bought. The basic mutation action, Kumar occurs in the nucleotides, not the phosphodiester backbone.

 

[Kumar]

Kumar,

You either did not go onto page two from your link or didn't understand it. Of course you focus on phosphates and sulphur; they're part of this "cell salts" pseudomedical nonsense you've bought. The basic mutation action, Kumar occurs in the nucleotides, not the phosphodiester backbone.

A nucleotide is a molecule containing three parts: a simple sugar called deoxyribose, a phosphate, and a special molecule called a nitrogen base. A DNA nucleotide can contain any one of four different nitrogen bases. These are adenine, thymine, guanine and cytosine. Nucleotides join together when the phosphate portion on one bonds with the sugar portion on another.

Can't there be any defect/problem in joints leading some defects in chain?

 

[BillHoyt]

Can't there be any defect/problem in joints leading some defects in chain?

Nicks and breaks in the phosphodiester backbone occur with relative frequency. They are not due to dietary considerations or absence of "cell salts," Kumar. When they occur, DNA ligases make repairs. When the repairs do not work, crossovers or frame shift mutations, etc., occur.

 

[Kumar]

Nicks and breaks in the phosphodiester backbone occur with relative frequency. They are not due to dietary considerations or absence of "cell salts," Kumar. When they occur, DNA ligases make repairs. When the repairs do not work, crossovers or frame shift mutations, etc., occur.

Means: these Nicks and breaks in the phosphodiester backbone can't be passed to new generations?

 

[MRC_Hans]

Means: these Nicks and breaks in the phosphodiester backbone can't be passed to new generations?

Affirmative!

Hans

 

[Kumar]

Mr.Hans,

Thanks for reply. Now other part of genetic substances:-

Chromosomes:

The Ovum:

Can't there be any defect/problem in chromosomes & Ovum (other structures than DNAs) makeups leading to some some defects fetus?


I want to furthur clear that how imbalances in internal environmental factors (pH,temp.etc.) of reproductive system can damage/mutate to gemete esp. sperms? These imbalances in internal environmental factors might had been influenced by outer env.factors(pollutions, modren lifestyle etc.) causing modern epidemic type outbreak in modern diseases like diabetes,HBP etc.

I couldn't yet get satisfactory reply to this question. Parts of reproductive systems senstive to env. imbalances may be prostate glands, vagina, testis...

 

[Anders]

Mr.Hans,

Thanks for reply. Now other part of genetic substances:-

Chromosomes:

Chromosoms ARE the genes. They are called chromosomes because they defined that way. A chromosom consists of two DNA strands in a double helix which has been condensed in a very complicated way, so complicated that we still don't know the whole picture. This folding of the DNA double helix is due to a few proteins, histones, and non-histones, and a few more. But, still, chromosoms are the DNA in eucaryotes. In procaryotes the DNA is shaped in a much simplier form.

 

[Kumar]

Chromosoms ARE the genes. They are called chromosomes because they defined that way. A chromosom consists of two DNA strands in a double helix which has been condensed in a very complicated way, so complicated that we still don't know the whole picture. This folding of the DNA double helix is due to a few proteins, histones, and non-histones, and a few more. But, still, chromosoms are the DNA in eucaryotes. In procaryotes the DNA is shaped in a much simplier form.

Thanks for explaining. Which aminoacids are in chromosomes protien? Are there some sulphur based amino acids there in Chr. protien? Can there be some defects in structure of these chromosome's protiens?

 

[Anders]

Thanks for explaining. Which aminoacids are in chromosomes protien? Are there some sulphur based amino acids there in Chr. protien? Can there be some defects in structure of these chromosome's protiens?

OK, well, the proteins of histones and all other proteins consisits of 20 different amino acids. There are two amino acids that has one sulphur atom, thats Cysteine, and Metheonine (spelling might be wrong, its hard enough to remember the names). These two are part of all proteins. And, Oh, those two are neither bases nor acids, i.e give nothing on pH. There are two acidic amino acids and three basic amino acids. BTW, the amino acids are not acids in proteins.

Proteins that are faulty in any way are destroyed. End of story. No the chromatin is very seldom damged, and if it is it doesn't really matter. Small errors pass without any problems, major damage kills the cell.

It quite fun this, I using this as a nice way to repeat my Biochemistry courses.

 

[Zep]

Mr.Hans,

Thanks for reply. Now other part of genetic substances:-

Chromosomes:

The Ovum:

Can't there be any defect/problem in chromosomes & Ovum (other structures than DNAs) makeups leading to some some defects fetus?


I want to furthur clear that how imbalances in internal environmental factors (pH,temp.etc.) of reproductive system can damage/mutate to gemete esp. sperms? These imbalances in internal environmental factors might had been influenced by outer env.factors(pollutions, modren lifestyle etc.) causing modern epidemic type outbreak in modern diseases like diabetes,HBP etc.

I couldn't yet get satisfactory reply to this question. Parts of reproductive systems senstive to env. imbalances may be prostate glands, vagina, testis...

Oh look. We are going at the same subject again but from a different angle this time, now that the previous attempt was beaten to death...

 

[flume]

Originally posted by Kumar: Are there some sulphur based amino acids there in Chr. protien?

Are you asking about sulfur-containing amino acids because you hope to make a connection with tissue salts (as Bill Hoyt suggested)?