Nightingale’s work was based in pre-germ-theory ideas about health and disease, and her concepts of illness reflected traditional humoral ideas about bodily balance and imbalance. However, in the 19th century, theories about zymotic, miasmatic, and other environmentally based sources of infection were predominant, and Nightingale took it as self-evident that filth, putrefaction, and decay—and the miasmic emanations they sent through the air—were the causes of individual diseases and epidemics. For the most part, she did not believe that diseases had specific identities, but, instead, believed that they could change from one disease to another. She also resisted the idea that disease could be contagious from person to person. To her, diseases and epidemics were caused entirely by environmental influences; this conviction was central in her evangelical devotion to hygiene and sanitation in hospitals. Nightingale advocated strongly for regular linen changing, adequate ventilation, the frequent emptying of chamber pots, and the regular scrubbing of floors and walls.
When the germ theory was developed after about 1870, Nightingale was skeptical of its importance, and remained convinced that hygienic practices were more valuable for health than knowledge of bacteriology.