While there is a great deal that of TOE that falls into #1-3, the skeptics maintain that somethings cannot be explained by mutation and natural selection alone.
Their claims, however, completely fail to stand up to the evidence presently available.
Therein lies the problem with their claims.
I can stand up right now and shout: INTERESTING IAN MADE US ALL 5 millseconds before you read this statement! (sorry, Ian, I'm not saying you assert that, just using you as an example)
But you can't produce any evidence to that effect. I've made a claim, but there is no evidence. Every claim that evolution deniers make that I've seen is similar, it's an unsupported claim of this or that, most often based on either on argument ad ignorantum, or on argumentup ad populum. Sometimes ID'ers and other creationists simply deny or ignore evidence in their claims, as well.
For instance, were I to stand up and shout: THE SUN NEVER SHINED, the sun is not very likely to go out, never mind it might not be shining where I can see it at the minute. People can SAY just about literally anything.
Even criticism has to have some support. Otherwise, we get into the deconstructionist paradigm that there are no facts. None the less, when you let go of the rock, it falls on your toe.