Weight change = calories in - calories out. Period.
All the other related concepts like insulin resistance, glucose indexs, leptin levels, will only explain the hunger cycles and appetite surges- "why we eat", not weight changes. Cetainly, when I get low enough glucose, I CAN drink a jar of strawberry jam, but the hypoglycemia does not make my stomache send me 'eat now' messages. Those come on schedule, from habit, and are not related to glucose levels. The low sugar shakiness works through a mental process, I know I ought to eat then, but it's not the normal hunger.
While I did best on the Zone diet, more appetite suppresion would be a good thing. Anybody got any drug samples?
I do believe that the metabolism of food digestion starts with the taste buds (seven kinds?) that send messages to the brain, which sends messages to the pancreas/liver/stomache as to which enzymes to put out. Some medicines even interupt these pathways to control sugar conversions. So, I'd think artificial sweeteners COULD cause some kind of changes.....Maybe if we made cooking fats taste like sugar, we wouldn't digest the fats? Or did they try something like that with an artificial fat- it caused bloating and anal leakage? Digestion tracts are not that simple....