Seriously ill volunteers after clinical trial treatment

[Rolfe]

Yes, I saw that. It's not an effect that would have put me off doing the human trial, I have to say, especially given what the drug was supposed to do.

My money's on this drug being too successfully engineered to target humans specifically, and whether or not it might work therapeutically, being something you really don't want to take if you've got a fully-functional immune system.

I suspect this will herald a whole new raft of safety precautions and intermediate tests for future studies, but it's all hindsight. Subject to possible revelations to the contrary, at the moment it seems to me reasonable that this was something out of the blue.

Rolfe.

 

[MRC_Hans]

I believe that phase 1 trials are very occasionally done on sick individuals, for example where the drug (perhaps something very cytotoxic) is considered too poisonous to subject a healthy person to. *snip*
Rolfe.

Sure. There can always be exceptions.

There are drugs where you aren't too worried about dangers, if the alternative is almost certain death.

And, as you mention, some drugs are dangerous to healthy persons, but not to sick ones. Insulin comes to mind ... again. ... And no doubt other replacement therapies.

Hans

 

[Badly Shaved Monkey]

NovoNordisk's Novoseven(tm) anticoagulant, which is originally developed for hemophiles, was given to an Israeli soldier who was hemorrhaging from bullet wounds, faster than they could infude new blood. He survived, and opened up a whole new indication for that drug.

anti-coagulant??

You've been mixing with the like-cures-like brigade for too long.

(Novoseven)

 

[MRC_Hans]

anti-coagulant??

You've been mixing with the like-cures-like brigade for too long.

(Novoseven)

Ooops .

NovoSeven is a coagulant.


Oh, well.....................


Hans

 

[Melendwyr]

And, as you mention, some drugs are dangerous to healthy persons, but not to sick ones. Insulin comes to mind ... again. ...

There are no such drugs. There are drugs that, in certain doses and administered in certain ways, are dangerous to healthy people but not sick (in specific ways) ones.

Insulin can kill, or cause serious brain damage. It can do so regardless of whether you're insulin-insufficient or not.