I think Kumar has already had the answers to all or most of these, but since some of them may be of general interest, let's recap:
Thanks for nice & clean reply.
This depends on which injected insulin you use. There are a number of different types; animal-derived, synthezised human insulin, and the new analogues. There are slight differences in the structure and content. Generally, the newest tend to cause fewer instances of allergy, etc.
Pls tell me the difference between synthezised human insulin/the new analogues and our endogenous insulin.
Is it true: "Injected insulin is more likely to disapate as it should in the proper times because its not resistant like a diabetic Type2's impaired insulin."
I have not heard of such an effect. Do you have a source?
It was replied to me at one sci.group, but unclear, but also dynamic thought.
No, whatever it means, that is not it. The main problem with insulin resistance is that the body cells have lost some of their ability to use insulin of any kind. However, the effect of insulin is partly dose-dendent, so injecting extra insulin may temporarily counteract insulin resistance.
You remeber carol at hapthy & other places indicated that our insulin become inferere in IR conditions. Anyway this can be thought that, if anything(insulin here) is excessivly exposed to our cells, & cells recognize that insuin, cells may opt for something not to accept action of that insulin to avoid hypoglymic severe effect. But if injected insulin is not recognized by cells, this insulin may then work. Now I am suspecting if oral insulin promoting medicines may be a reason for getting IR condition by promoting our insulin recognised by our cells.
Neither can cause insulin resistance, but it is suspected that constant high levels of insulin in the blood can speed up the progress of insulin resistance.
I previously suspected this "somewhat alike indigestion of insulin to cells". Do you know the theory behind "insulin in the blood can speed up the progress of insulin resistance"?
3. Excess insulin in blood can mean "hyperinsulinemia" & it can be a common condition in type2 with IR patients.
Type 2 diabetes is defined as a condition that is characterized by more or less progressed insulin resistance. In the early stages, the body copes by releasing extra insulin, so in the early stages of an untreated type 2 diabetes, high insulin levels are common.
A known complication is that insulin production suffers in the long run; after a time (usually years), the insulin production cannot cope any longer and drops off.
A putative complication is that consistent high insulin levels may increase the insulin resistance.[/b]
Many CV problems, atherosclerosis (most heart problems related to diabetes) are related to hyperinsulinemia. Major reason is that excess insulin will convert sugar into lipids, increase weight & cause CV problems.
As you can see, the body's natural reaction to insulin resistance is short-sighted: It helps right away, but in the long run makes the disease worse.
If it comes out at one day that medicines or injected insulin leads to IR then these medications can be considered as responsible for IR & worsening of diabetes--probably. Many thoughts indicate alike it.
Cause, no, because excess insulin in a person that does not have insulin resistance will cause a hypogluchaemic condition. Therefore, insulin resistance must always come first. Add to, maybe. As I told you, there is a suspicion that this is the case. Obviously, it is difficult to experiment with this.
Yes, that is right but IR can be triggered since pre-diabetes stage, on ocassional, irregular & excessive eating habits due to predisposition to that. This will lead to excess & irregular insulin secretions SO can cause IR condition. Medications with temporary controlling BG, may add to IR.
In addition, I have more questions for you:-
It cannot tell the whole story. Diabetes is a complex condition, and many factors are needed to get the whole story of each patient; lipids, kidney condition, BP, and more. A good diabetes center will make a long row of tests and examinations.Again it is not type 2 OR insulin resistance, it is AND. T
he choice between oral medicine and injected insulin (for type 2) depends on whether the individual patient is producing sufficient insulin. As long as this is the case, you will treat with oral medicine only. As the disease progresses, the insulin production falls off, and must be supplemented.
Just consider, When no medications: Insulin test & C-peptide tests can tell our insulinin blood. If excess, it can indicate IR, if low then type2/IDDM. When on medicines: C-peptide can tell our insulin & Insulin test can tell total insulin. Elevated C-peptide here can mean IR where lower type2/IDDM. Insulin test will tell total Insulin including injected one, if elevated can tell hyperinsulinemia. If we can know all these in early stages, an't it cover every basic story of diabetes?
One might say that inhaled insulin is distributed quicker to the blood-stream. However, the claim that the efficacy is better is dubious. For instance, much larger doses are needed with this method.
The main reason several companies are developing insulin inhalers remains the fact that many patients would go far to avoid self-injecting.
How can be think somewhat cephalic type effect & ingestion of insulin in monomeric/single/diluted form?
It indicates that the reaction time to injected insulin is not quite optimal, however, that is not the main problem in insulin treatment. The main problem is to always match the body's very variable demand.
Pls think about concentration of molecules & structure of molecules in this regards. Can concentration of insulin in crystal form & not coming into monomer form be a reson of IR & T2?
Furthur to above, I am also thinking about water blocks, Na/K ATP pump problem, mucus blocks etc in this regard.
What mucus deposits & its blocks can effect to absorption of sugar? One thought indicated more sugar absorption by this mucus other less absorption of it & other minerals etc. Mostly it should result more absorption of sugar but less of other nutrients.
