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Anti-inflammatories for depression?

Frozenwolf150

Formerly SilentKnight
Joined
Dec 10, 2007
Messages
4,134
I was reading over this article when I came across the first item on the list. (Several relevant links are embedded in the article itself.) I have noticed that whenever I take an OTC painkiller with anti-inflammatory properties, I feel a little better in terms of my mood. So I asked my psychiatrist about this. She said that the studies are in their preliminary experimental stages, but nothing has yet been FDA approved. She said that if I'm interested, I should look up a clinical trial of anti-inflammatory drugs for treatment of mental illness, although I'm not entirely sure how to do that. The other factor is obviously proper diet. Certain foods increase inflammation while others decrease it. I already know about the alleged benefits of omega-3 fatty acids. Dietary changes are something I can do on my own, but I want to make sure I'm doing it the right way, and that I'm not chasing down another dead end.

Does anyone know anything about the use of anti-inflammatories to treat mental illness?
 
I was reading over this article when I came across the first item on the list. (Several relevant links are embedded in the article itself.) I have noticed that whenever I take an OTC painkiller with anti-inflammatory properties, I feel a little better in terms of my mood. So I asked my psychiatrist about this. She said that the studies are in their preliminary experimental stages, but nothing has yet been FDA approved. She said that if I'm interested, I should look up a clinical trial of anti-inflammatory drugs for treatment of mental illness, although I'm not entirely sure how to do that. The other factor is obviously proper diet. Certain foods increase inflammation while others decrease it. I already know about the alleged benefits of omega-3 fatty acids. Dietary changes are something I can do on my own, but I want to make sure I'm doing it the right way, and that I'm not chasing down another dead end.

Does anyone know anything about the use of anti-inflammatories to treat mental illness?

I'm curious about the part I highlighted. Is that true?
 
I'm curious about the part I highlighted. Is that true?

That's the thing, I'm still trying to find out about this myself, which is why I was asking. I suppose I should have phrased that as a question. I can't find any research papers on this, however sites like this one claim that omega-3 fatty acids and antioxidants act as anti-inflammatories, while omega-6 fatty acids do the opposite. I've found these claims on arthritis treatment sites as well.

At this point, I'm willing to try anything to get rid of my depression.
 
amitryptiline is a long-known medicine for both migraines and depression, which would seem to support your theory.
 
I've been taking anti-inflammatories for so many decades that it is now impossible to tell if they have any effect on mood or condition. I've had bouts of depression, regardless. But I've noticed the effect you mention when taking low doses of antibiotics, I think mainly because any uptick in health and energy does help my mood.

For depression that is not entirely incapacitating, I find strenuous manual labor is great. I just get into the rote activity slowly at first, and as I build up a sweat and energize, I feel better in general. My other two non-pharma solutions are to get as much sunlight as possible, and to listen to comedy tapes. While I cannot stomach a movie when depressed, good comedians can usually can get through at some point.
 
I was reading over this article when I came across the first item on the list. (Several relevant links are embedded in the article itself.) I have noticed that whenever I take an OTC painkiller with anti-inflammatory properties, I feel a little better in terms of my mood. So I asked my psychiatrist about this. She said that the studies are in their preliminary experimental stages, but nothing has yet been FDA approved. She said that if I'm interested, I should look up a clinical trial of anti-inflammatory drugs for treatment of mental illness, although I'm not entirely sure how to do that. The other factor is obviously proper diet. Certain foods increase inflammation while others decrease it. I already know about the alleged benefits of omega-3 fatty acids. Dietary changes are something I can do on my own, but I want to make sure I'm doing it the right way, and that I'm not chasing down another dead end.

Does anyone know anything about the use of anti-inflammatories to treat mental illness?

I have noticed some of the same results.
When I take ibuprofen, depression seems better. I thought that, maybe, all the small irritants and minor pain lessening, just made me feel much better. Seem to be just as crazy, just in a better mood.The stuff acts like a mild sleeping pill for me.
Maybe I'm just a cheap date.
 
That's the thing, I'm still trying to find out about this myself, which is why I was asking. I suppose I should have phrased that as a question. I can't find any research papers on this, however sites like this one claim that omega-3 fatty acids and antioxidants act as anti-inflammatories, while omega-6 fatty acids do the opposite. I've found these claims on arthritis treatment sites as well.

At this point, I'm willing to try anything to get rid of my depression.

I've looked a lot of info about that in recent years and use it with myself. I can tell you it is about true.

A summary of what I can tell -and, sorry, I am not going to engage in large discussions nor paper hunting about that, least when half what I've read is in Spanish-:

  • Two essential fatty acids needed: 18:3 (n-3) -we eat something between too little and way too little- and 18:3 (n−6) -we eat something between what we need or too much-.
  • Your body can elaborate other fatty acids from them using different enzymes called elongases -making the carbon chain longer (20, 22, atoms)- and desaturases -adding additional double carbon bondings-. By these ways are created eicosanoids (polyunsaturated 20-carbon fatty acids) that are the fundamental basis of dozens of hormones. The most famous: EPA (eicosapentaenoic acid) -the good guy- and AA (arachidonic acid) -the not as good as the other guy-.
  • From those eicosanoids your body creates leukotrienes, prostanoid galore (prostaglandins, prostacyclins, tromboxanes) and a whole lot more including even endocannabinoids.
  • Depending on what ecoicosanoid they departed, the different the effect. If they were created from EPA, they tend to be anti-inflammatory. If created from AA, not so.
  • You can also eat food containing EPA and AA.
  • From EPA (and not from AA), the same enzymes creates DHA 22:6(n-3) (omega-3 polyunsaturated fatty acid with 22 carbons) which is the essential to brain tissue and has been shown to relatively protect you (moderate, delay) against a bunch of mental disorders, mainly those which tend to become worse with ageing.
  • You also can eat food containing DHA.
I have even experimented with myself changing diet and can tell these results. I went all omega-6 (very easy to do) and ate all that is reputed as inflammatory -sugars and starch, for instance-. Then I went as all omega-3 as I could (not easy) and also took food with other anti-inflammatory nutrients or slightly diuretic, like adding a couple of celery stalks and a spoon of parsley in my soup. The result was a loss of 4.7 Kg (a bit above 10 pounds) of weight in 48 hours and without cutting calories -of course I regained an intermediate weight when I went back to a normal diet. Not only that, my blood pressure dropped by 10-5 mmHg, joint and other minor pains vanished and I was much more flexible. I was in a much better mood, but most probably because of a general "I feel good" state. I repeated it in three different occasions with similar results.

So I learned a lot -and still learning- about what to eat and without being a fanatic I try to follow a healthier diet -I've just taken a coleslaw with chia seeds and high-oleic mayo as "five o'clock tea" just because I indulged my sweet tooth at lunch-

About depression, diet including natural anti-inflammatories and physical exercise, have showed to be of much help, specially in the long term. But there's no substitute for a proper therapy including medicines and introspection, all guided by specialists.
 
  • Two essential fatty acids needed: 18:3 (n-3) -we eat something between too little and way too little- and 18:3 (n−6) -we eat something between what we need or too much-.
  • Your body can elaborate other fatty acids from them using different enzymes called elongases -making the carbon chain longer (20, 22, atoms)- and desaturases -adding additional double carbon bondings-. By these ways are created eicosanoids (polyunsaturated 20-carbon fatty acids) that are the fundamental basis of dozens of hormones. The most famous: EPA (eicosapentaenoic acid) -the good guy- and AA (arachidonic acid) -the not as good as the other guy-.
  • From those eicosanoids your body creates leukotrienes, prostanoid galore (prostaglandins, prostacyclins, tromboxanes) and a whole lot more including even endocannabinoids.
  • Depending on what ecoicosanoid they departed, the different the effect. If they were created from EPA, they tend to be anti-inflammatory. If created from AA, not so.
  • You can also eat food containing EPA and AA.
  • From EPA (and not from AA), the same enzymes creates DHA 22:6(n-3) (omega-3 polyunsaturated fatty acid with 22 carbons) which is the essential to brain tissue and has been shown to relatively protect you (moderate, delay) against a bunch of mental disorders, mainly those which tend to become worse with ageing.
  • You also can eat food containing DHA.

Thanks for the information.

I just have one request. Could you be more specific about the types of foods to which you were referring?
 
Thanks for the information.

I just have one request. Could you be more specific about the types of foods to which you were referring?

Yes. Let me round off previous information first.

To have a change in proportions of your hormones, leukotrienes, for instance, by eating food containing AA or much gamma-linoleic acid -18:3 (n−6)- you foster leukotrienes-4, and by eating food containing EPA or much alfa-linoleic acid -18:3 (n-3)- you foster leukotrienes-5. The latter favour bonchodilation so it has been found that diet has an influence in asthma and allergic rhinitis.

So you may regulate the fatty acids you eat by reducing the intake of omega-6, and increasing the intake of omega-3 and omega-9 (the last are neutral and help to acquire a balance). Let's start for those with shorter carbon chain:

  • 18-carbon
    • to reduce omega-6: Avoid soybean oil, corn oil, peanut oil, cottonseed oil, common sunflower oil, common safflower oil. Use with caution canola oil, hemp oil, high-oleic sunflower oil, high-oleic safflower oil, high-oleic peanut oil (they either have a good proportion of omega-6 and omega-3, or little omega-6 and almost none omega-3, so they help you to balance your diet but they're not "the solution" if you don't change other items). Also reduce the ingest of animal fat when the cattle, poultry of fish are fed with common grains. Farmed salmon may be the doppelgänger of wild salmon. Grass fed animals are OK but you have all the saturated fats you should avoid for different reasons (Anyway, we have to die of something, haven't we?)
    • to increase omega-9: use olive oil.
    • to increase omega-3: eat chia seeds, linseed/flax (horrible as it is)
    • As a general rule, read nutrition facts and ingredients and be careful about supplements, pills and trendy products like spirulina or nattoo. Supplements are not vaccines: you can't take a chia oil capsule and then go fetch your Colonel Sanders bucket.
  • 20/22-carbon (for direct effects)
    • to decrease AA: Avoid most sausages; good quality I-can-see-chunks-in-it sausages can be consumed, a premium Italian salami for instance; but the hot dog like or liverwurst are a no-no. Avoid tripe and other inner organs.
    • to increase EPA and DHA: Eat fish, tons of fish from colder ocean waters. Canned fish is OK but for it to be really good you have to avoid those from tropical seas or those canned during local summer. I go to a wholesaler to buy packages of Argentine tuna, sardine and anchovy and Chilean jack mackerel canned in August -southern winter-. Eat a little fish as frequent as you can. A can of sardines here, a couple of Alaskan surimi steaks there. Two or three full meals with fish per week. Farmed fish -except mussel- is a no-no because they are fed pellets containing omega-6 fatty acids and not the algae containing omega-3 fatty acids that are the base of the sea food chain.
And about other food, as a general rule reduce sugars and starches and increase leaf vegetables. You have to learn by yourself: for instance potatoes and sweet potatoes are similar in calories but potatoes are much inflammatory, specially those cheap flakes to make instant mashed potato that are manufactured from damaged tubers (potatoes defend themselves with toxins and only a long cooking can get rid of those). On the contrary, sweet potatoes are just mildly inflammatory.

If you want to learn by yourself, you can get some rules of thumb from browsing http://nutritiondata.self.com/ and looking for the inflammation factor rating. My favourite natural "pseudo anti-inflammatories" are spinach, parsley and garlic, all fresh and as raw as possible.

And don't look only for inflammation factors and fatty acids as you may conclude that tons of vitamin A is good for you when in fact minor excesses increase cancer rates. As a general rule eat natural food -no need for it to be organic, or grass fed, or from happy animals with a bell in their neck- and not supplements. When you read "this pill contains as much vitamin XYZ as 20 cantaloupes", well, who'd eat 20 cantaloupes? then, who'd need 20 cantaloupes? The most probably outcome is you having to XYZ. Also be cautious with natural supplements like cod liver oil, because you may get healthy fatty acids but lots of vitamin A and D you don't need. Never say "I will swallow a spoon of cod liver oil a day to replenish my reserves of DHA and EPA because you'd be getting a near dangerous level of vitamin A with that -if you eat your carrots- and a dose of vitamin D that only a sub-Saharan African living in Northern Norway would need during Winter.

Also exert caution about interactions with medicines and always tell your physician you're on a diet heavy in this or that. For instance, if you eat lots of EPA, avoid AA like sin and also take aspirin daily to protect your heart -or worse, you take a couple of aspirins for any cause- you may go to the dentist to pull a tooth or any other more modern surgery and you may end up with a serious problem to stop the bleeding. Consult your physician as the same don't necessary apply with other surgeries.
 
I was reading over this article when I came across the first item on the list. (Several relevant links are embedded in the article itself.) I have noticed that whenever I take an OTC painkiller with anti-inflammatory properties, I feel a little better in terms of my mood. So I asked my psychiatrist about this. She said that the studies are in their preliminary experimental stages, but nothing has yet been FDA approved. She said that if I'm interested, I should look up a clinical trial of anti-inflammatory drugs for treatment of mental illness, although I'm not entirely sure how to do that. The other factor is obviously proper diet. Certain foods increase inflammation while others decrease it. I already know about the alleged benefits of omega-3 fatty acids. Dietary changes are something I can do on my own, but I want to make sure I'm doing it the right way, and that I'm not chasing down another dead end.

Does anyone know anything about the use of anti-inflammatories to treat mental illness?

There has been interest in markers of inflammation in depression and mental illness
http://journals.lww.com/co-psychiat...matory_mechanisms_in_major_depressive.12.aspx

http://journals.lww.com/co-psychiat...matory_mechanisms_in_major_depressive.12.aspx

I did find this positive preliminary trial of celebrex for depression:

http://www.nature.com/mp/journal/v11/n7/abs/4001805a.html

although this has not entered mainstream practice AFAIK (not my specialty)

This meta analysis did not find an effect of NSAIDS in schizophrenia:

http://schizophreniabulletin.oxfordjournals.org/content/early/2013/05/29/schbul.sbt070.short

Hope these links help in your search for information.
 
I find that Tylenol helps with some things. I have mild social anxiety (i.e. I'm shy). It's worse some days, for example I'll actually be embarrased to walk down the hallway at work. After taking a tylenol I notice it gets better. Also when I can't sleep in the middle of the night with anxious thoughts, if I take a tylenol they go away and I fall asleep within a half hour.

Not scientific at all of course since I started this after reading an article about it.
 

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